EPSRC - Centre for Innovative Manufacturing in Regenerative Medicine

Peter Archibald

Peter Archibald cropped

  • PhD Student
  • Loughborough University
  • T: +44 (0)1509 564889
  • E: 

 

PhD title:

Using clinical demand and technological solutions to accelerate the adoption of mesenchymal stem cell based therapies for simultaneous indications

 

PhD supervisor:

Prof David Williams

 

PhD summary:

My project aims to:

  • Examine the mechanisms behind human mesenchymal stem cell (hMSC) paracrine mode of action and its potential in the targeting of multiple simultaneous indications
    • Examine the effect of alternative process steps upon this mode of action
  • Comparison of automated and manual cell culture methods- Examine the effects of alternative process steps upon properties and characteristics of multiple cell types, including hMSCs, human embryonic stem cells and a reference cell line
  • Adapt current healthcare product appraisal methods to account for the treatment of multiple indications
  • Examine the opportunity for reimbursement of regenerative  medicine products in the new value-based pricing scheme
  • Skills/techniques:
    • Laboratory programme
      • Automated cell culture (CompacT SelecT)
      • Manual cell culture process step (centrifugation)
      • Measurements of cell quality for each cell line (viability, cell number, cell number over time)
      • Characterisation of each cell line (markers, morphology)
      • Examining biomarkers of hMSC mode of action

Presentations, publications, awards:

Loughborough University Health and Life Sciences Research School 2013 Conference – Delegate Choice Poster Award