As well as filing patents for the protection of new manufacturing tools and technologies, EPSRC Centre members publish a significant number of peer-reviewed journal articles right across the breadth of the science and engineering literature. Below is a list of our publications since the beginning of our funding grant in September 2010. Also, you can find most articles about engineering or order buy term papers online at https://top-papers.com/buy-term-papers-online/ There you can find the topic you need very quickly.
Each article has a weblink included where you will be able to view the publication – in some cases this may involve a subscription-based journal website. If you would like a copy of any of the articles mentioned, please contact us.
2016
Dixon JE, Osman G, Morris GE, Markides H, Rotherham M, Bayoussef Z, El Haj AJ, Denning C & Shakesheff KM (2016). Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides. Weblink
2015
Hourd P, Medcalf N, Segal J, Williams DJ (2015). A 3D bioprinting exemplar of the consequences of the regulatory requirements on customized processes. Weblink
Archibald PRT, Williams DJ (2015). Using the cost–effectiveness of allogeneic islet transplantation to inform induced pluripotent stem cell-derived β-cell therapy reimbursement. Weblink
Bubela T, McCabe C, Archibald P, Atkins H, Bradshaw SE, Kefalas P, Mujoomdar M, Packer C, Piret J, Raxworthy M, Soares M, Viswanathan S (2015). Bringing regenerative medicines to the clinic: the future for regulation and reimbursement. Weblink
Wilson SL, Sidney LE, Dunphy SE, Dua HS, Hopkinson A (2015). Corneal Decellularization: A Method of Recycling Unsuitable Donor Tissue for Clinical Translation? Weblink
Heathman TRJ, Stolzing A, Fabian C, Rafiq QA, Coopman K, Nienow AW, Kara B, Hewitt CJ (2015). Serum-free process development: improving the yield and consistency of human mesenchymal stromal cell production. Weblink
Patel AK, Celiz AD, Rajamohan D, Anderson DG, Langer R, Davies MC, Alexander MR, Denning C (2015). A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays. Weblink
Archibald PRT, Chandra A, Thomas D, Morley G, Lekishvili T, Devonshire A, Williams DJ (2015). Comparability of scalable, automated hMSC culture using manual and automated process steps. Weblink.
Heathman TRJ, Rafiq QA, Chan AKC, Coopman K, Nienow AW, Kara B, Hewitt CJ (2015). Characterisation of human mesenchymal stem cells from multiple donors and the implications for large scale bioprocess development. Weblink.
Celiz A, Smith JGW, Patel AK, Hook AL, Rajamohan D, George VT, Patel MJ, Epa VC, Singh T, Langer R, Anderson DG, Allen ND, Hay DC, Winkler DA, Barrett DA, Davies MC, Young LE, Denning C, Alexander MR (2015). Discovery of a novel polymer for human pluripotent stem cell expansion and multi-lineage differentiation. Weblink.
Thurman-Newall JA, Petzing JN, Williams DJ (2015). Qualification of variation in biological input materials and its effect on clinical outcome and manufacture. Weblink.
Rose J, May M and Williams DJ (2015). Determinants of clinician adoption of regenerative therapies in the UK and Canada: an ophthalmology perspective. Weblink.
Medcalf N, Hourd P, Chandra A and Williams DJ (2015). Quality assurance and GMP in the manufacture of cell-based therapeutics. Weblink.
Bulman S, Coleman C, Murphy M, Medcalf N, Ryan A and Barry F. Pullulan: a new cytoadhesive for cell-mediated cartilage repair. Weblink.
Regenerative Medicine a UK pathway (2015). Weblink.
French A, Bravery C, Smith J, Chandra A, Archibald P, Gold JD, Artzi N, Kim HW, Barker RW, Meissner A, Wu JC, Knowles JC, Williams DJ, García-Cardeña G, Sipp D, Oh S, Loring JF, Rao MS, Reeve B, Wall I, Carr AJ, Bure K, Stacey G, Karp JM, Snyder EY, Brindley DA (2015). Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards. Weblink.
Heathman T.R.J, Glyn V, Picken A, Rafiq Q.A, Coopman K, Nienow A.W, Kara B and Hewitt C.J.(2015). Expansion, harvest and cryopreservation of human mesenchymal stem cells in a serum-free microcarrier process. Weblink.
Silver M, Daheron L, Hurley H, Bure K, Barker R, Carr A, Williams D, Kim HW, French A, Coffey P, Cooper-White J, Reeve B, Rao M, Snyder E, Nq K, Mead B, Smith J, Karp J, Brindley D and Wall I (2015). Generating iPSCs: Translating Cell Reprogramming Science into Scalable and Robust Biomanufacturing Strategies. Weblink.
Hussein H, Williams DJ, Liu Y (2015). Design modification and optimisation of the perfusion system of a tri-axial bioreactor for tissue engineering. Weblink.
Heathman, T. R. J., Neinow, A. W., McCall, M. J, Coopman., K., Kara, B and Hewitt, C. J (2015). The translation of cell-based therapies: clinical landscape and manufacturing challenges. Weblink.
Hourd, P., Chandra, A., Alvey, D., Ginty, P. J., McCall, M. J., Ratcliffe, E., Rayment, E and Williams, D. J. (2015). Qualification of academic facilities for small-scale automated manufacture of autologous cell-based products (Regenerative Medicine Special Report). Weblink
Win Naing, M., Gibson, Hourd, P., Gomez, S. G., Horton, R. B. V., Segal, J and Williams, D. J (2015). Improving umbilical cord blood processing to increase total nucleated cell count yield and reduce cord input wastage by managing the consequences of input variation. Weblink
Win Naing, M., Gibson, D. A., Hourd, P., Gomez, S. G., Horton, R. B. V., Segal, J. and Williams, D. J. (2015). Improving umbilical cord blood processing to increase total nucleated cell count yield and reduce cord input wastage by managing the consequences of input variation. Cytotherapy, in press. Weblink
Saeed, A., Francini, N., White, L., Dixon, J., Gould, T., Rashidi, H., Cheikh Al Ghanami, R., Hruschka, V., Redl, H., Saunders, B. R., Alexander, C. and Shakesheff, K. M. (2015). A thermoresponsive and magnetic colloid for 3D cell expansion and reconfiguration. Adv. Mater., in press. Weblink
Sidney, L. E., Heathman, T. R. J., Britchford, E. R., Abed, A., Rahman, C. V. and Buttery, L. D. K. (2015). Investigation of localized delivery of diclofenac sodium from poly(D,L-lactic acid-co-glycolic acid)/poly(ethylene glycol) scaffolds using an in vitro osteoblast inflammation model. Tissue Eng. Part A, in press. Weblink
2014
Akram, K. M., Spiteri, M. A. and Forsyth, N. R. (2014). Activin-directed differentiation of human embryonic stem cells differentially modulates alveolar epithelial wound repair via paracrine mechanism. Stem Cell Discov., 4, 67-82. Weblink
Bayon, Y., Vertès, A. A., Ronfard, V., Egloff, M., Snykers, S., Franco Salinas, G., Thomas, R. J., Girling, A., Lilford, R., Clermont, G. and Kemp, P. (2014). Translating cell-based regenerative medicines from research to successful products: Challenges and solutions. Tissue Eng. B., 20, 246-256. Weblink
Celiz, A. D., Smith, J. G. W., Langer, R., Anderson, D. G., Winkler, D. A., Barrett, D. A., Davies, M. C., Young, L. E., Denning, C. and Alexander, M. R. (2014). Materials for stem cell factories of the future. Nature Mater., 13, 570-579. Weblink
Celiz A. D., Smith J., Patel, A. K., Langer R., Anderson, D. G., Barrett, D. A., Young, L., Davies, M. C., Denning, C. and Alexander, M. R. (2014). Chemically diverse polymer microarrays and high throughput surface characterisation: A method for discovery of materials for stem cell culture. Biomater. Sci., 2, 1604-1611. Weblink
Chan, A. K. C., Heathman, T. R. J., Coopman, K. and Hewitt, C. J. (2014). Multiparameter flow cytometry for the characterisation of extracellular markers on human mesenchymal stem cells. Biotech. Lett., 36, 731-741. Weblink
Chippendale, T. W. E., Spanel, P., Smith, D. and El Haj, A. J. (2014). Counting cell number in situ by quantification of dimethyl sulphide in culture headspace. Analyst, 139, 4903-4907. Weblink
Coopman, K. and Medcalf, N. (2014). From production to patient: challenges and approaches for delivering cell therapies. StemBook, ed. The Stem Cell Research Community. Weblink
Dale-Black, S. H. (2014). Careers in the developing regenerative medicine sector. Orthopaedic Product News, issue 160, May 2014. Weblink
Dixon, J. E., Shah, D. A., Rogers, C., Hall, S., Weston, N., Parmenter, C. D. J., McNally, D., Denning, C. and Shakesheff, K. M. (2014). Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation. Proc. Natl. Acad. Sci. USA, 111, 5580-5585. Weblink
Dong, C.-L., Webb. W. R., Peng, Qiang, Tang, J. Z., Forsyth, N. R., Chen, G.-Q- and El Haj, A. J. (2014). Sustained PDGF-BB release from PHBHHx loaded nanoparticles in 3D hydrogel/stem cell model. J. Biomed. Mater. Res., in press. Weblink
Dunphy, S. E., Bratt, J. A. J., Akram, K. M., Forsyth, N. R. and El Haj, A. J. (2014). Hydrogels for lung tissue engineering: Biomechanical properties of thin collagen–elastin constructs. J. Mech. Bev. Biomed. Mater., in press. Weblink
Farrugia, M., Morgan, S. P., Alexander, C. and Mather, M. (2014). Ultrasonic monitoring of drug loaded Pluronic F127 micellular hydrogel phase behaviour. Mat. Sci. Eng. B, 34, 280-286. Weblink
Heathman, T. R. J., Webb, W. R., Han, J., Dan, Z., El Haj, A. J., Zhang, Z. R. and Sun, X. (2014). Controlled production of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) nanoparticles for targeted and sustained drug delivery. J. Pharm. Sci., 103, 2498-2508. Weblink
Henstock, J. R., Rotherham, M., Rashidi, H., Shakesheff, K. M. and El Haj, A. J. (2014). Remotely activated mechanotransduction via magnetic nanoparticles promotes mineralization synergistically with bone morphogenetic protein 2: Applications for injectable cell therapy. Stem Cells Translat. Med., 3, 1363-1374. Weblink
Hourd, P., Chandra, A., Alvey, D., Ginty, P., McCall, M., Ratcliffe, E., Rayment, E. and Williams, D. J. (2014). Qualification of academic facilities for small-scale automated manufacture of autologous cell-based products. Regen. Med., 9, 799-815. Weblink
Hourd, P., Chandra, A., Medcalf, N. and Williams, D. J. (2014). Regulatory challenges for the manufacture and scale-out of autologous cell therapies. StemBook, ed. The Stem Cell Research Community. Weblink
Hourd, P., Ginty, P., Chandra, A., Williams, D. J. (2014). Manufacturing models permitting roll out/scale out of clinically led autologous cell therapies: regulatory and scientific challenges for comparability. Cytotherapy, 16, 1033-1047. Weblink
Hu, B., Dobson, J. and El Haj, A. J. (2014). Control of smooth muscle α-actin (SMA) up-regulation in HBMSCs using remote magnetic particle mechano-activation. Nanomed. Nanotech. Biol. Med., 10, 45-55. Weblink
Kehoe, O., Cartwright, A., Askari, A., El Haj, A. J. and Middleton, J. (2014). Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis. J. Transl. Med., 12:157. Weblink
Kumar, D., Gerges, I., Tamplenizza, M., Lenardi, C., Forsyth, N. and Liu, Y. (2014). Three-dimensional hypoxic culture of human mesenchymal stem cells encapsulated in a photocurable, biodegradable polymer hydrogel: A potential injectable cellular product for nucleus pulposus regeneration. Acta Biomater., 10, 3463-3474. Weblink
Mitchell, P. D., Ratcliffe, E., Hourd, P., Williams, D. J., and Thomas, R. J. (2014). A quality-by-design approach to risk reduction and optimization for hESC cryopreservation processes. Tissue Eng. C, 20, in press. Weblink
Nienow, A. W., Rafiq, Q. A., Coopman, K. and Hewitt, C. J. (2014). A potentially scalable method for the harvesting of hMSCs from microcarriers. Biochem. Eng. J., 85, 79-88. Weblink
Nikolaev, N. I., Müller, T., Williams, D. J., Liu, Y. (2014). Changes in the stiffness of human mesenchymal stem cells with the progress of cell death as measured by atomic force microscopy. J. Biomech., 47, 625-630. Weblink
Ratcliffe, E., Thomas, R. J. and Stacey, A. J. (2014). Visualizing medium and biodistribution in complex cell culture bioreactors usingin vivo imaging. Biotech. Progress, 30, 256-260. Weblink
Reinwald, Y., Leonard,. K. H. L., Henstock, J. R., Whiteley, J. P., Osborne, J. M., Waters, S. L., Levesque, P. and El Haj, A. J. (2014). Evaluation of the growth environment of a hydrostatic force bioreactor for preconditioning of tissue-engineered constructs. Tissue Engineering Part C: Methods, in press. Weblink
Rogers, C. M., Deehan, D. J., Knuth, C. A., Rose, F. R. A. J., Shakesheff, K. M. and Oldershaw, R. A. (2014). Biocompatibility and enhanced osteogenic differentiation of human mesenchymal stem cells in response to surface engineered poly(d,l-lactic-co-glycolic acid) microparticles. J. Biomed. Mater. Res., 102, 3872-3882. Weblink
Rogers, C. M., Morris, G. E., Gould, T. W. A., Bail, R., Toumpaniari, S., Harrington, H., Dixon, J. E., Shakesheff, K. M., Segal, J. and Rose, F. R. A. J. (2014). A novel technique for the production of electrospun scaffolds with tailored three-dimensional micro-patterns employing additive manufacturing. Biofabrication, 6, in press. Weblink
Rose, J. B., Pacelli, S., El Haj, A. J., Dua, H. S., Hopkinson, A., White, L. J. and Rose, F. R. A. J. (2014). Gelatin-based materials in ocular tissue engineering. Materials, 7, 3106-3135. Weblink
Sicilia, G. Grainger-Boultby, C., Francini, N., Magnusson, J. P., Saeed, A. O., Fernandez-Trillo, F., Spain, S. G. and Alexander, C. (2014). Programmable polymer-DNA hydrogels with dual input and multiscale responses. Biomater. Sci., 2, 203-211. Weblink
Sidney, L. E., Kirkham, G. R. and Buttery, L. D. (2014). Comparison of osteogenic differentiation of embryonic stem cells and primary osteoblasts revealed by responses to IL-1β, TNF-α, and IFN-γ. Stem Cells Dev., 23, 605-617. Weblink
Soares, F. A. C., Chandra, A., Thomas, R. J., Pedersen, R. A., Vallier, L., Williams, D. J. (2014). Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions. J. Biotechnol., 173, 53-58. Weblink
Sule-Suso, J., Forsyth, N. R., Untereiner, V. and Sockalingum, G. D. (2014). Vibrational spectroscopy in stem cell characterisation: is there a niche? Trends in Biotech., 32, 254-262. Weblink
Akram, K. M., Samad, S., Spiteri, M. A. and Forsyth, N. ( ). Mesenchymal stem cells promote alveolar epithelial cell wound repair in vitro through distinct migratory and paracrine mechanisms. Respiratory Research, 14, issue 9. Weblink
Akram, K. M., Samad, S., Spiteri, M. and Forsyth, N. R. ( ). Mesenchymal stem cell therapy and lung diseases. Adv. Biochem. Eng. Biotech., 130, 105-129. Weblink
Brindley, D. A., French, A., Suh, J., Roberts, M., Davies, B., Pinedo-Villanueva, R., Wartolowska, K., Rooke, K., Kramm, A., Judge, A., Morrey, M., Chandra, A., Hurley, H., Grover, L., Bingham, I., Siegel, B., Rattley, M. S., Buckler, R. L., McKeon, D., Krumholz, K., Hook, L., May, M., Rikabi, S., Pigott, R., Morys, M., Sabokbar, A., Titus, E., Laabi, Y., Lemaitre, G., Zahkia, R., Sipp, D., Horne, R., Bravery, C., Williams, D. J., Wall, I., Snyder, E. Y., Karp, J. M., Barker, R. W., Bure, K., Carr, A. J., and Reeve, B. ( ). The implementation of novel collaborative structures for the identification and resolution of barriers to pluripotent stem cell translation. Stem Cells Dev., 22, 63-72. Weblink
Brosnan, K., Want, A., Coopman, K. and Hewitt, C. J. ( ). Multiparameter flow cytometry for the characterization of human embryonic stem cells. Biotech. Lett., 35, 55-65. Weblink
Cunha-Reis, C., El Haj, A. J., Yang, X. and Yang, Y. ( ). Fluorescent labeling of chitosan for use in non-invasive monitoring of degradation in tissue engineering. J. Tissue Eng. Reg. Med., 7, 39-50. Weblink
Curran, J. M., Fawcett, S., Hamilton, L., Rhodes, N. P., Rahman, C. V., Alexander, M., Shakesheff, K. and Junt, J. A. ( ). The osteogenic response of mesenchymal stem cells to an injectable PLGA bone regeneration system. Biomaterials, 34, 9352-9364. Weblink
Ginai, M., Elsby, R., Hewitt, C. J., Surry, D., Fenner, K. and Coopman, K. ( ). The use of bioreactors as in vitro models in pharmaceutical research. Drug Discov. Today, 18, 922-935. Weblink
Glen, K. E., Workman, V. L., Ahmed, F., Ratcliffe, E., Stacey, A. J. and Thomas, R. J. ( ). Production of erythrocytes from directly isolated or Delta1 Notch ligand expanded CD34+ hematopoietic progenitor cells: process characterization, monitoring and implications for manufacture. Cytotherapy, 15, 1106-1117. Weblink
Gould, T. W. A., Birchall, J. P., Mallick, A. S., Alliston, T., Lustig, L. R., Shakesheff, K. M. and Rahman, C. V. ( ). Laryngoscope, 123, 3156-3161. Weblink
Henstock, J. R., Rotherham, M., Rose, J. B. and El Haj, A. J. ( ). Cyclic hydrostatic pressure stimulates enhanced bone development in the foetal chick femur in vitro. Bone, 53, 468-477. Weblink
Hruschka, V., Meinl, A., Saeed, A., Cheikh Al Ghanami, R., Redl, H., Shakesheff, K. and Wolbank, S. ( ). Gelatin embedding for the preparation of thermoreversible or delicate scaffolds for histological analysis. Biomed. Mater., 8, 041001. Weblink
Hu, B. and El Haj, A. J. ( ). Methionine sulfoxide reductase A as a marker for isolating subpopulations of stem and progenitor cells used in regenerative medicine. Med Hypotheses, 80, 663-665. Weblink
Hu, B., El Haj, A. J. and Dobson, J. ( ). Receptor-targeted, magneto-mechanical stimulation of osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Int. J. Mol. Sci., 14, 19276-19293. Weblink
Iftimia-Mander, A., Hourd, P., Dainty, R. and Thomas, R. J. ( ). Mesenchymal stem cell isolation from human umbilical cord tissue: Understanding and minimizing variability in cell yield for process optimization. Biopreservation and Biobanking, 11, 291-298. Weblink
Lomas, A. J., Webb, W. R., Han, J., Chen, G.-Q., Sun, X., Zhang, Z., El Haj, A. J. and Forsyth, N. R. ( ). Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate)/collagen hybrid scaffolds for tissue engineering applications. Tissue Eng. C, 19, 577-585. Weblink
Markides, H., Kehoe, O., Morris, R. H. and El Haj, A. J. ( ). Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells – a rheumatoid arthritis mouse model. Stem Cell Research & Therapy, 4, 126. Weblink
McCall, M. J. and Williams, D. J. ( ). Developing cell therapies: Enabling cost prediction by value systems modeling to manage developmental risk. J. Comm. Biotech., 19, 27-39. Weblink
Naing, M. W., Liu, Y., Sebastine, I., Dingmann, D., Williams, C. and Williams, D. J. ( ). Design and validation of a physiologically-adapted bioreactor for tissue engineering of the nucleus pulposus, Processes, 2, 1-11. Weblink
Nienow, A. W., Rielly, C. D., Brosnan, K., Bargh, N., Lee, K., Coopman, K. and Hewitt, C. J. ( ). The physical characterisation of a microscale parallel bioreactor platform with an industrial CHO cell line expressing an IgG4. Biochem. Eng. J., 76, 25-36. Weblink
Nienow, A. W., Scott, W. H., Hewitt, C. J., Thomas, C. R., Lewis, G., Amanullah, A., Kiss, R. and Meier, S. J. ( ). Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture. Chem. Eng, Res. Des., 91, 2265-2274. Weblink
O’Dea, R. D., Osborne, J. M., El Haj, A. J., Byrne, H. M. and Waters, S. L. ( ). The interplay between tissue growth and scaffold degradation in engineered tissue constructs. J. Math. Biol., 67, 1199-1225. Weblink
Pijanka, J. K., Stone, N., Rutter, A. V., Forsyth, N., Sockalingum, G. D., Yang, Y. and Sule-Saso, J. ( ). Identification of different subsets of lung cells using Raman microspectroscopy and whole cell nucleus isolation. Analyst, 138, 5052-5058. Weblink
Quatchi, O., Shakesheff, K. M. and Buttery, L. D. ( ). Delivery of definable number of drug or growth factor loaded poly(dl-lactic acid-co-glycolic acid) microparticles within human embryonic stem cell derived aggregates. J. Control. Release, 168, 18-27. Weblink
Rafiq, Q. A., Brosnan, K. M., Coopman, K., Nienow, A. W. and Hewitt, C. J. ( ). Culture of human mesenchymal stem cells on microcarriers in a 5 l stirred-tank bioreactor. Biotech. Lett., 35, 1233-1245. Weblink
Rafiq, Q. A., Coopman, K. and Hewitt, C. J. ( ). Scale-up of human mesenchymal stem cell culture: current technologies and future challenges. Curr. Opin. Chem. Eng., 2, 8-16. Weblink
Rafiq, Q. A., Coopman, K., Nienow, A. W. and Hewitt, C. J. ( ). A quantitative approach for understanding small-scale human mesenchymal stem cell culture – implications for large-scale bioprocess development. Biotech. J., 8, 459-471. Weblink
Ratcliffe, E., Glen, K. E., Naing, M. W. and Williams, D. J. ( ). Current status and perspectives on stem cell-based therapies undergoing clinical trials for regenerative medicine: case studies. Brit. Med. Bull., 108, 73-94. Weblink
Ratcliffe, E., Hourd, P., Guijarro-Leach, J., Rayment, E., Williams, D. J. and Thomas, R. J. ( ). Application of response surface methodology to maximize the productivity of scalable automated human embryonic stem cell manufacture. Regen. Med., 8, 39-48. Weblink
Reinwald, Y., Johal, R. K., Ghaemmaghami, A. M., Rose, F. R. A. J., Howlde, S. M. and Shakesheff, K. M. ( ). Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution. Polymer, 55, 435-444. Weblink
Sawkins, M. J., Bowen, W., Dhadda, P., Markides, H., Sidney, L. E., Taylor, A. J., Rose, F. R. A. J., Badylak, S. F., Shakesheff, K. M. and White, L. J. ( ). Hydrogels derived from demineralized and decellularized bone extracellular matrix. Acta Biomater., 9, 7865-7873. Weblink
Shahidan, N. N., Alexander, C., Shakesheff, K. M. and Saunders, B. R. ( ). Gelation of microsphere dispersions using a thermally-responsive graft polymer. J. Colloid Interf. Sci., 396, 187-196. Weblink
Shahidan, N. N., Liu, R., Thaiboonrod, S., Alexander, C., Shakesheff, K. M. and Saunders, B. R. ( ). Hollow colloidosomes prepared using accelerated solvent evaporation. Langmuir, 29, 13676-13685. Weblink
Sharp, D. M. C., Picken, A., Morris, T. J., Hewitt, C. J., Coopman, K. and Slater N. K. H. ( ). Amphipathic polymer-mediated uptake of trehalose for dimethyl sulfoxide-free human cell cryopreservation. Cryobiology, 67, 305-311. Weblink
Tang, M., Purcell, M., Steele, J. A. M., Lee, K.-Y., McCullen, S., Shakesheff, K. M., Bismarck, A., Stevens, M. M., Howdle, S. M. and Williams, C. K. ( ). Porous copolymers of ε-caprolactone as scaffolds for tissue engineering. Macromolecules, 46, 8136-8143. Weblink
Watson, N. J., Johal, R. K., Glover, Z., Reinwald, Y., White, L. J., Ghaemmaghami, A. M., Morgan, S. P., Rose, F. R. A. J., Povey, M. J. W. and Parker, N. G. ( ). Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport. Mater. Sci. Eng. C, 33, 4825-4832. Weblink
Webb, W. R., Dale, T. P., Lomas, A. J., Zeng, G., Wimpenny, I., El Haj, A. J., Forsyth, N. R. and Chen, G.-Q. ( ). The application of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tendon repair in the rat model. Biomaterials, 34, 6683-6694. Weblink
Whittall, C., Kehoe, O., King, S., Rot, A., Patterson, A. and Middleton, J. ( ). A chemokine self-presentation mechanism involving formation of endothelial surface microstructures. J. Immunol., 190, 1725-1736. Weblink
Williams, D. J., Ridgway, K., Clegg, C. W., Hourd, P., Robinson, M., Bolton, L., Cichomska, K. and Baldwin, J. ( ). The factory of the future – A study for the Department of Business, Innovation and Skills. The National Metals Technology Centre University of Sheffield AMRC, Rotherham, UK. Weblink
Wilson, S. L., Yang, Y. and El Haj, A. J. ( ). Corneal stromal cell plasticity: In vitro regulation of cell phenotype through cell-cell interactions in a three-dimensional model. Tissue Eng. A, 20, 225-238. Weblink
2012
Akram, K. M., Lomas, N. J., Spiteri, M. A. and Forsyth, N. R. (2012). Club cells inhibit alveolar epithelial wound repair via TRAIL-dependent apoptosis. Eur. Respir. J., 41, 683-694. Weblink
Ali, K. H. M., Williams, D. J., Jackson, P. and Pau, H. P. (2012). Attitudes of the UK ear, nose and throat clinical community to the future potential use of stem cell therapies to treat deafness. Regen. Med., 7, 179-186. Weblink
Almeida, R. D., Loose, M., Sottile, V., Matsa, E., Denning, C., Young, L., Johnson, A. D., Gering, M. and Ruzov, A. (2012). 5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development. Epigenetics, 7, 383-389. Weblink
Cartwright, A., King, S., Middleton, J. and Kehoe, O. (2012). Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency of CCR9 in a Murine Model of Antigen-Induced Arthritis. Open J. Rheum. Autoimmun. Diseases, 2, 77-84. Weblink
Chippendale, T. W. E., Hu, B., El Haj, A. J. and Smith, D. (2012). A study of enzymatic activity in cell cultures via the analysis of volatile biomarkers. Analyst, 137, 4677-4685. Weblink
Ghita, A., Pascut, F. C., Mather, M., Sottile, V. and Notingher, I. (2012). Cytoplasmic RNA in undifferentiated neural stem cells: A potential label-free raman spectral marker for assessing the undifferentiated status. Anal. Chem., 84, 3155-3162. Weblink
Kelly, C. A., Naylor, A., Illum, L., Shakesheff, K. M. and Howdle, S. M. (2012). Supercritical CO2: A clean and low temperature approach to blending PDLLA and PEG. Adv. Funct. Mater., 22, 1684–1691. Weblink
Lemon, G., Reinwald, Y., White, L. J., Howdle, S. M., Shakesheff, K. M. and King, J. R. (2012). Interconnectivity analysis of supercritical CO2-foamed scaffolds. Comput. Meth. Prog. Bio., 106, 139-149. Weblink
Lomas, A. J., Chen, G. G. Q., El Haj, A. J. and Forsyth, N. R. (2012). Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) supports adhesion and migration of mesenchymal stem cells and tenocytes. World J. Stem Cells, 4, 94-100. Weblink
Lomas, N. J., Watts, K. L., Akram, K. M., Forsyth, N. J. and Spiteri, M. A. (2012). Idiopathic pulmonary fibrosis: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic markers. Int. J. Clin. Exp. Pathol., 5, 58-71. Weblink
Morris, D. E., Mather, M. L., Simon, C. G. Jr. and Crowe, J. A. (2012). Time-optimized X-ray micro-CT imaging of polymer based scaffolds. J. Biomed. Mater. Res. Part B, 100B, 360–367. Weblink
Morris, S. A., Grewal, S., Barrios, F., Patankar, S. N., Strauss, B., Buttery, L., Alexander, M., Shakesheff, K. M. and Zernicka-Goetz, M. (2012). Dynamics of anterior–posterior axis formation in the developing mouse embryo. Nature Comm., 3, article 673. Weblink
Nikolaev, N. I., Liu, Y., Hussein, H. and Williams, D. J. (2012). The sensitivity of human mesenchymal stem cells to vibration and cold storage conditions representative of cold transportation. J. R. Soc. Interface, 9, 2503-2515. Weblink
Paik, I., Scurr, D. J., Morris, B., Hall, G., Denning, C., Alexander, M. R., Shakeshedd, K. M. and Dixon, J. E. (2012). Rapid micropatterning of cell lines and human pluripotent stem cells on elastomeric membranes. Biotech. Bioeng., 109, 2630-2641. Weblink
Rahman, C. V., Saeed, A., White, L. J., Gould, T. W. A., Kirby, G. T. S., Sawkins, M. J., Alexander, C., Rose, F. R. A. J. and Shakesheff, K. M. (2012). Chemistry of polymer and ceramic-based injectable scaffolds and their applications in regenerative medicine. Chem. Mater., 24, 781-795. Weblink
Ratcliffe, E., Glen, K. E., Workman, V. L. Stacey, A. J. and Thomas, R. J. (2012). A novel automated bioreactor for scalable process optimisation of haematopoietic stem cell culture. J. Biotech., 161, 387-390. Weblink
Rogers, C. M., Woolley, T. S., Cruwys, S. C., Buttery, L. D. K., Rose, F. R. A. J. and Shakesheff, K. M. (2012). Engineering an in-vitro model of rodent cartilage. J. Pharm. Pharmacol., 64, 821–831. Weblink
Rose, J. B. and Williams, D. J. (2012). The UK relative to other single payer-dominated healthcare markets for regenerative medicine therapies. Regen. Med., 7, 429-438. Weblink
Sharma, P., Hughes, S., El Haj, A., Maffulli, N. (2012). Expression of the two pore domain potassium channel TREK-1 in human intervertebral disc cells. Curr. Stem Cell Research & Therapy, 7, 266-271. Weblink
Shin, E., Forsyth, N. R. and Fricker, R. A. (2012). The effect of physiological oxygen levels on GABAergic neuronal differentiation from mouse embryonic stem cells. Stem Cell Studies, 2, 13-20. Weblink
Tayton, E., Purcell, M., Aarvold, A., Smith, J. O., Kalra, S., Briscoe, A., Shakesheff, K., Howlde S. M., Dunlop, D. G., Oreffo, R. O. C. (2012). Supercritical CO2 fluid-foaming of polymers to increase porosity: A method to improve the mechanical and biocompatibility characteristics for use as a potential alternative to allografts in impaction bone grafting? Acta Biomater., 8, 1918-1927. Weblink
Want, A. J., Nienow, A. W., Hewitt, C. J. and Coopman, K. (2012). Large-scale expansion and exploitation of pluripotent stem cells for regenerative medicine purposes: beyond the T flask. Regen. Med., 7, 71-84. Weblink
Williams, D. J., Thomas, R. J., Hourd, P. C., Chandra, A., Ratcliffe, E., Liu, Y., Rayment, E. A., and Archer, J. R. (2012). Precision manufacturing for clinical-quality regenerative medicines. Phil. Trans. R. Soc. A, 370, 3924-3949. Weblink
Wilson, S. L., Wimpenny, I., Ahearne, M., Rauz, S., El Haj, A. J. and Yang, Y. (2012). Chemical and topographical effects on cell differentiation and matrix elasticity in a corneal stromal layer model. Adv. Funct. Mater., 22, 3641-3649. Weblink
Wimpenny, I., Markides, H., El Haj, A. J. (2012). Orthopaedic applications of nanoparticle-based stem cell therapies. Stem Cell Research & Therapy, 3:13. Weblink
Zhang, H., Kay, A., Forsyth, N. R., Liu, K.-K. and El Haj, A. J. (2012). Gene expression of single human mesenchymal stem cell in response to fluid shear. J. Tissue Eng., 3, 2041731412451988. Weblink
2011
Chippendale, T. W. E., Coopman, K., Rafiq, Q., El Haj, A., Hewitt, C. J. (2011). Isolation of mesenchymal stem cells from bone marrow aspirate. In Comprehensive Biotechnology, 2nd Edition, Vol 5 Medical Biotechnology and Healthcare. Editor: Moo Young M. 115-123. Elsevier. Weblink
Dey, S., Kellam, B., Alexander, M. R., Alexander, C. and Rose, F. R. A. J. (2011). Enzyme-passage free culture of mouse embryonic stem cells on thermo-responsive polymer surfaces. J. Mater. Chem., 21, 6883-6890. Weblink
El Haj, A. J. (2011). Engineering cells to grow tissue. Ingenia, 49, 22-28. Weblink
Ginty, P. J., Rayment, E. A., Hourd, P. and Williams, D. J. (2011). Regenerative medicine, resource and regulation: lessons learned from the remedi project. Regen. Med., 6, 241-253. Weblink
Gomes, N. M. V., Ryder, O. A., Houck, M. L., Charter, S. J., Walker, W., Forsyth, N. R., Austad, S. N., Venditti, C., Pagel, M., Shay, J, W. and Wright, W. E. (2011). Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell, 10, 761-768. Weblink
Griffiths, S. L., Griffiths, D. and Forsyth, N. R. (2011). Mesenchymal stem-cell-based therapy for the older patient. Aging Health, 7, 447-452. Weblink
Hewitt, C. J., Lee, K., Nienow, A. W., Thomas, R. J., Smith, M. and Thomas, C. R. (2011). Expansion of human mesenchymal stem cells on microcarriers. Biotech. Lett., 33, 2325-2335. Weblink
Naing, M. W. and Williams, D. J. (2011). Three-dimensional culture and bioreactors for cellular therapies. Cytotherapy, 13, 391–399. Weblink
Oliva, F., Gatti, S., Porcellini, G., Forsyth, N. R., Maffulli, N. (2011). Growth factors and tendon healing. In: Rotator Cuff Tear. Med Sport Sci. Maffulli N (Ed.). Basel, Karger, 57, 53–64. Weblink
Ratcliffe, E., Thomas, R. J. and Williams, D. J. (2011). Current understanding and challenges in bioprocessing of stem cell-based therapies for regenerative medicine. Brit. Med. Bull., 100 , 137-155. Weblink
Shahidan, N. N., Liu, R., Cellesi, F., Alexander, C., Shakesheff, K. M. and Saunders, B. R. (2011). Thermally triggered assembly of cationic graft copolymers containing 2-(2-methoxyethoxy)ethyl methacrylate side chains. Langmuir, 27, 13868-13878. Weblink
Thomas, R. J. and Ratcliffe, E. (2011). Automated adherent human cell culture (mesenchymal stem cells). In: Human cell culture protocols, 806, 393-406. Weblink
Williams, D. J and Chandra, A. (2011). A complete system for producing autologous cells for use in regenerative medicine. Innovation in Healthcare, 3, 83-85. Weblink
Williams, D. J. (2011). Overcoming manufacturing and scale-up challenges. Regen. Med., 6, 67-69. Weblink
Williams, D. J. (2011). Regenerative medicine, a unique opportunity to transform our national health and wealth, needs capability in manufacturing and supply. Innovation in Healthcare, 2, 42-44. Weblink
2010
Alexander, C. and Gill, I. (2010). Responsive materials. MRS Bull., 35, 659-664. Weblink